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Immune Imprinting in the Influenza Ferret Model
Amanda L Skarlupka1, Ted M Ross1,2
1Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Abstract:
The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations. Animal models that are used to investigate influenza pathogenesis and vaccination do recapitulate the pre-immune history in the human population. The establishment of influenza pre-immune ferret models is necessary for understanding infection and transmission and for designing efficacious vaccines.
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