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Updated: Dec 24, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Brief episodes of rapid irregular atrial activity (micro-AF) are a risk marker for atrial fibrillation: a prospective
Tove Fredriksson1, Katrin Kemp Gudmundsdottir2, Viveka Frykman2
1Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, 182 88, Stockholm, Sweden. tove.fredriksson@sll.se.
Background:
Short supraventricular tachycardias with atrial fibrillation (AF) characteristics are associated with an increased risk of developing AF over time. The aim of this study is to determine if presence of very short-lasting episodes of AF-like activity (micro-AF) can also be used as a marker of undiagnosed silent atrial fibrillation.
Methods:
In the STROKESTOP II study, a Swedish mass screening study for AF among 75- and 76-year-olds, participants with NT-proBNP ≥125 ng/L performed intermittent ECG recordings 30 s, four times daily for 2 weeks. Participants with micro-AF (sudden onset of irregular tachycardia with episodes of ≥5 consecutive supraventricular beats and total absence of p-waves, lasting less than 30 s) were invited to undergo extended AF screening using continuous event recording for 2 weeks. A control group of individuals without micro-AF was examined using the same ECG modalities.
Results:
Out of 3763 participants in STROKESTOP II who had elevated NT-proBNP levels and were free of AF, n = 221 (6%) had micro-AF. The majority of participants with micro-AF (n = 196) accepted further investigation with continuous ECG monitoring which showed presence of AF in 26 of them. In the control group (n = 250), continuous monitoring detected 7 new AF cases. Thus, AF was significantly more common in the micro AF group (13%) compared to the control group (3%), p < 0.001.
Conclusions:
Presence of short-lasting episodes of AF-like activity (micro-AF) indicates increased likelihood for undetected AF. Continuous screening therefore seems recommendable if a finding of AF would change clinical management.
Trail Registration:
ClinicalTrials.gov, identifier: NCT02743416, registered April 19, 2016.
Insights
Short episodes of atrial fibrillation-like activity (micro-AF) can indicate undiagnosed silent atrial fibrillation (AF). Continuous screening is recommended for individuals with micro-AF, as it significantly increases the likelihood of detecting AF.
Area of Science:
- Cardiology
- Electrophysiology
- Preventive Medicine
Background:
- Short supraventricular tachycardias with atrial fibrillation (AF) characteristics are linked to a higher risk of developing AF.
- Undiagnosed silent atrial fibrillation poses a significant health risk.
Purpose of the Study:
- To determine if very short-lasting episodes of AF-like activity (micro-AF) can serve as a marker for undiagnosed silent atrial fibrillation.
- To assess the prevalence of micro-AF in an elderly population screened for AF.
Main Methods:
- The STROKESTOP II study screened 75- and 76-year-olds with elevated NT-proBNP using intermittent ECGs.
- Participants with micro-AF (defined as irregular tachycardia with absence of P-waves, <30s) underwent extended continuous ECG monitoring.
- A control group without micro-AF was also monitored.
Main Results:
- 6% of participants (221/3763) with elevated NT-proBNP and no prior AF diagnosis had micro-AF.
- AF was detected in 26/196 (13%) of the micro-AF group during extended monitoring.
- AF was detected in 7/250 (3%) of the control group, a statistically significant difference (p < 0.001).
Conclusions:
- The presence of micro-AF suggests a higher likelihood of undetected atrial fibrillation.
- Continuous ECG screening is recommended for individuals with micro-AF, especially if AF detection influences clinical management.
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