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Updated: Dec 24, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
Konrad H Stopsack1, Lorelei A Mucci2, Emmanuel S Antonarakis3
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.
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