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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Acute Kidney Injury I: Introduction01:22

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Related Experiment Video

Updated: Dec 24, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Toward Patient-Centered Innovation: A Conceptual Framework for Patient-Reported Outcome Measures for Transformative

Jennifer E Flythe1,2, Tandrea S Hilliard3, Kourtney Ikeler3

  • 1Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina Kidney Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Clinical Journal of the American Society of Nephrology : CJASN
|April 12, 2020
PubMed
Summary

Kidney patients need better quality of life measures. This study developed a framework to identify patient-reported outcome measures (PROMs) for kidney replacement therapy (KRT) clinical trials.

Keywords:
Patient Reported Outcome MeasuresPatient-Centered CarePublic-Private Sector PartnershipsRenal InsufficiencyRenal Replacement TherapyUnited States Food and Drug Administrationclinical trialdialysisend-stage renal diseasehemodialysisinnovationkidneymedical devicespatient prioritiespatient-reported outcomesquality of liferenal dialysis

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TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
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Last Updated: Dec 24, 2025

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Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Patient-Reported Outcomes

Background:

  • Dialysis patients face significant declines in function and well-being.
  • Kidney replacement therapy (KRT) has seen limited technological innovation.
  • Patient perspectives are crucial for developing effective KRT.

Purpose of the Study:

  • To develop a conceptual framework for health-related quality of life patient-reported outcome measures (PROMs).
  • To identify and map existing PROMs to this framework for regulatory use.
  • To outline steps for selecting PROMs in KRT clinical trials.

Main Methods:

  • Convened a workgroup under the Kidney Health Initiative.
  • Developed a conceptual framework for health-related quality of life PROMs.
  • Mapped and prioritized existing PROMs based on regulatory evidence.

Main Results:

  • A conceptual framework for health-related quality of life PROMs was proposed.
  • Existing PROMs were mapped and prioritized for regulatory application.
  • Gaps and future needs for PROM development were identified.

Conclusions:

  • Rigorous and meaningful PROMs are essential for transformative KRT clinical trials.
  • Incorporating patient priorities into PROM selection is critical.
  • This work advances the development of PROMs for KRT innovation.