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Fibrocalculous Pancreatic Diabetes
Ranjit Unnikrishnan1,2, Viswanathan Mohan3,4
1ICMR Centre for Advanced Research on Diabetes, Madras Diabetes Research Foundation, No 4, Conran Smith Road, Gopalapuram, Chennai, 600 086, India.
Current Diabetes Reports
|April 12, 2020
Summary
Fibrocalculous pancreatic diabetes (FCPD) is a severe diabetes form found in developing nations. Recent evidence suggests a declining prevalence, possibly due to environmental factors interacting with genetic susceptibility.
Area of Science:
- Endocrinology
- Gastroenterology
- Epidemiology
Background:
- Fibrocalculous pancreatic diabetes (FCPD) is a rare diabetes subtype predominantly affecting underprivileged populations in developing countries.
- Characterized by pancreatic calcifications and diabetes, FCPD presents unique clinical and management challenges.
Purpose of the Study:
- To review the latest evidence on the epidemiology, trends, etiopathogenesis, and treatment of FCPD.
- Focus on studies published within the last decade.
Main Methods:
- Comprehensive literature search of recent studies on FCPD.
- Analysis of epidemiological data, etiological factors, and therapeutic approaches.
Main Results:
- Limited new data on FCPD emerged in the past decade, with a reported decline in prevalence.
- Emerging evidence suggests FCPD arises from unknown environmental factors acting on a genetic predisposition.
- FCPD is associated with a higher risk of pancreatic adenocarcinoma.
Conclusions:
- FCPD remains an under-recognized condition despite its severity and potential premalignant nature.
- Further research is warranted to understand its etiology, trends, and optimal management strategies.
- Increased attention is needed due to FCPD's unique features and association with pancreatic cancer.
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