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Curcumin Improves Biomolecules Associated with Renal Function and Attenuates Oxidative Injury and Histopathological

Seun F Akomolafe1, Tosin A Olasehinde2,3, Omowumi O Adewale4

  • 1Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria. seun.akomolafe@eksu.edu.ng.

Biological Trace Element Research
|April 12, 2020
PubMed

Insights

Curcumin protects against kidney damage caused by potassium bromate (KBrO3) in rats. It improves kidney function, antioxidant status, and reduces harmful histopathological changes, demonstrating its protective effects.

Area of Science:

  • Biochemistry
  • Toxicology
  • Pharmacology

Background:

  • Potassium bromate (KBrO3) is a nephrotoxic agent causing significant renal damage.
  • Investigating natural compounds for renoprotective effects is crucial for managing kidney toxicity.

Purpose of the Study:

  • To evaluate the protective effect of curcumin against KBrO3-induced renal damage in vivo.
  • To assess the impact of curcumin on kidney biomarkers, enzyme activities, and oxidative stress markers.

Main Methods:

  • Rats were treated with KBrO3 to induce renal damage.
  • Curcumin was administered orally to assess its protective effects.
  • Kidney function biomarkers, enzyme activities (ADA, arginase), nitric oxide, antioxidant enzymes (SOD, CAT, GPX), and lipid peroxidation (MDA) were measured.

Main Results:

  • KBrO3 significantly increased kidney damage markers and altered enzyme activities.
  • Curcumin treatment significantly reduced kidney damage markers and normalized enzyme activities.
  • Curcumin improved antioxidant status by increasing SOD, CAT, GPX, and GSH levels while decreasing MDA.
  • Histopathological examination showed curcumin ameliorated KBrO3-induced kidney tissue damage.

Conclusions:

  • Curcumin exhibits significant renoprotective effects against KBrO3-induced nephrotoxicity in rats.
  • Curcumin's protective mechanism involves improving antioxidant defense and mitigating histopathological damage.
  • Curcumin demonstrates potential as a therapeutic agent for preventing or treating kidney damage.
Keywords:
Adenosine deaminaseAntioxidantsArginaseCurcuminPotassium bromateRenal function

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