Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

50.9K
Overview
50.9K
Allergic Reactions02:06

Allergic Reactions

31.7K
Overview
31.7K
Cross-reactivity00:42

Cross-reactivity

32.7K
Overview
32.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Active versus Passive Immunity01:31

Active versus Passive Immunity

9.7K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
9.7K
Immunological Memory01:23

Immunological Memory

14.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microcrystalline tyrosine as a novel depot-forming agent in venom immunotherapy: a pre-clinical evaluation in bee-venom allergic mice.

Frontiers in allergy·2026
Same author

γδ T cells at the interface of innate and adaptive immunity in cancer.

Journal for immunotherapy of cancer·2026
Same author

A Case for Anti-IgE Vaccination.

Allergy·2026
Same author

Patient preference in allergen immunotherapy - Understanding the patient's view.

The World Allergy Organization journal·2026
Same author

Correction: Gerstlauer et al. TAPAS-A Prospective, Multicentre, Long-Term Cohort Study in Children, Adolescents and Adults with Seasonal Allergic Rhinitis-Design and Early Results. <i>J. Clin. Med.</i> 2025, <i>14</i>, 2609.

Journal of clinical medicine·2025
Same author

Assessing the Allergenic Relevance of Vespula alascensis Venom: Implications for Venom Immunotherapy.

Journal of investigational allergology & clinical immunology·2025

Related Experiment Video

Updated: Dec 24, 2025

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

23.9K

Vaccination against Allergy: A Paradigm Shift?

Martin F Bachmann1, Mona O Mohsen2, Matthias F Kramer3

  • 1Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of BioMedical Research, Immunology RIA, Inselspital, University of Bern, Bern, Switzerland.

Trends in Molecular Medicine
|April 12, 2020
PubMed
Summary

New allergy immunotherapy strategies focus on IgG antibodies, not just IgE. Advances in antigen-carrier design and vaccine technology may lead to breakthroughs in treating allergic diseases.

Keywords:
SITVLPallergyvaccination

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.7K
Murine Model of Epicutaneously-Induced Immunomodulation
09:06

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

357

Related Experiment Videos

Last Updated: Dec 24, 2025

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

23.9K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.7K
Murine Model of Epicutaneously-Induced Immunomodulation
09:06

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

357

Area of Science:

  • Immunology
  • Allergy Research
  • Vaccine Development

Background:

  • Immunoglobulin E (IgE) antibodies are known mediators of allergic reactions.
  • Conventional immunotherapy mechanisms and the induction of immune tolerance are complex and debated.
  • There is a need for novel vaccine strategies to treat allergies.

Purpose of the Study:

  • To discuss the role of Immunoglobulin G (IgG) antibodies as a key effector in specific immunotherapy.
  • To explore advances in antigen-carrier design for next-generation allergy treatments.
  • To consider the potential of modern vaccine technology in allergy immunotherapy.

Main Methods:

  • Review of existing research on allergy mechanisms and immunotherapy.
  • Discussion of novel insights into IgG antibody function in immunotherapy.
  • Analysis of advancements in antigen-carrier systems for vaccine development.

Main Results:

  • Emerging evidence suggests IgG antibodies are a primary effector modality in specific immunotherapy.
  • Innovations in antigen-carrier design offer new possibilities for allergy vaccine development.
  • Historical experiments provide a foundation for modern immunotherapy approaches.

Conclusions:

  • IgG antibodies represent a promising target for next-generation allergy immunotherapies.
  • Advances in antigen-carrier technology are crucial for developing effective allergy vaccines.
  • The field is poised for breakthroughs in allergy treatment, building on over a century of research.