Cell-mediated immune response of goats to leptospirosis

Cell-mediated immunity to Leptospira pomona was measured in goats by the leukocyte-migration inhibition test (LMIT) and microassay for stimulation of protein synthesis (SPS) with 3H-leucine. L. pomona soluble antigen was used in both tests. The migration indices in the group of goats infected with L. pomona were significantly lower (less than .001) as compared to control. The migration zones of the unstimulated peripheral blood leukocytes in the infected group were significantly smaller (less than .001) than those of the control. The SPS test was strongly positive in test animals and was negative in control.