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Cognitive evoked potential (P300): a metric for cerebral concussion
R Pratap-Chand1, M Sinniah, F A Salem
1Department of Medicine, University Hospital, Kubang Kerian, Kelantan, Malaysia.
Acta Neurologica Scandinavica
|September 1, 1988
Summary
Minor head injuries, or concussions, can cause cognitive impairment. A P300 evoked potential test effectively measures cerebral dysfunction following concussion, showing abnormalities that resolve with recovery.
Area of Science:
- Neuroscience
- Clinical Neurophysiology
Background:
- Cognitive impairment is a known consequence of minor head injuries (concussions).
- Assessing cerebral dysfunction after concussion requires sensitive diagnostic tools.
Purpose of the Study:
- To evaluate the P300 evoked potential as a measure of cerebral concussion.
- To compare P300 abnormalities in patients with minor head injuries to normal subjects.
Main Methods:
- Studied 20 patients with minor head injuries and 20 healthy controls.
- Measured P300 latency and amplitude in post-concussion patients.
- Performed repeat testing to observe changes over time.
Main Results:
- Patients exhibited significant abnormalities in P300 latency and amplitude post-concussion.
- These P300 abnormalities showed complete improvement upon repeat testing.
- The study discusses the correlation of P300 findings with other head injury parameters.
Conclusions:
- The P300 evoked potential is a sensitive indicator of cerebral dysfunction following concussive head injuries.
- P300 testing offers a simple laboratory method for assessing concussion-related brain changes.