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Pertussis in Lao PDR: Seroprevalence and disease

Daria Kleine1, Somxay Billamay2, Phetsavanh Chanthavilay3

  • 1Department of Infection and Immunity, Luxembourg Institute of Health, 1445 Strassen, Esch-sur-Alzette, Luxembourg.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|April 12, 2020
PubMed

Insights

Pertussis (whooping cough) is common in Lao PDR, with over half the population showing exposure. Preschoolers had the highest recent infection rates, indicating a need to strengthen pertussis vaccination programs.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Pertussis (whooping cough) is a significant vaccine-preventable disease.
  • Understanding pertussis epidemiology is crucial for effective control strategies.

Purpose of the Study:

  • To assess pertussis susceptibility and exposure across various age groups and subpopulations in Lao PDR.
  • To identify specific populations at higher risk for pertussis.

Main Methods:

  • Serological testing for anti-pertussis toxin IgG antibodies in 3072 serum samples from diverse cohorts.
  • PCR analysis of respiratory samples from symptomatic children to detect Bordetella pertussis.

Main Results:

  • Overall pertussis seroprevalence was 57.5%.
  • Prevalence of recent infection/vaccination was highest in preschoolers (21.4%) compared to adults (7.4%).
  • Bordetella pertussis was detected in 1.05% of symptomatic children in Vientiane.

Conclusions:

  • Routine childhood vaccination, especially outreach, and healthcare worker vaccination require strengthening.
  • Consideration for childhood boosters and maternal pertussis vaccination is recommended.
  • Improved pertussis surveillance, reporting, and central testing facilities are necessary.
Abstract

Keywords:
Bordetella pertussisLao PDRSeroprevalenceVaccine immunogenicityVaccine-preventable infection

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