Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.3K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.3K
Overview of Cell Signaling01:23

Overview of Cell Signaling

23.6K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
23.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity.

Viruses·2015
Same author

Diffraction in a stratified region of a high numerical aperture Fresnel zone plate: a simple and rigorous integral representation.

Optics express·2015
Same author

Comparative Genetics of Seed Size Traits in Divergent Cereal Lineages Represented by Sorghum (Panicoidae) and Rice (Oryzoidae).

G3 (Bethesda, Md.)·2015
Same author

[Recent Researches on Optical in vivo Imaging: a review].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2015
Same author

[An analysis of relevant factors influencing the prognosis of post cardiac arrest syndrome].

Zhonghua wei zhong bing ji jiu yi xue·2015
Same author

Transparent ALD-grown Ta2O5 protective layer for highly stable ZnO photoelectrode in solar water splitting.

Chemical communications (Cambridge, England)·2015
Same journal

High-foaming modified walnut protein enhances milk coffee quality and volatile aroma profile.

Ultrasonics sonochemistry·2026
Same journal

Ultrasound-assisted deep eutectic solvent extraction of tyrosinase inhibitors from lotus seed peel powder.

Ultrasonics sonochemistry·2026
Same journal

Sonochemical cavitation-driven interfacial-selective nucleation of silver nanoparticles via silver carboxylate precursors for Ag/Si nanocomposites.

Ultrasonics sonochemistry·2026
Same journal

Scale-Dependent hydroxyl radical generation and energy efficiency in vortex diode hydrodynamic cavitation: machine learning insights toward industrial-scale applications in water treatment.

Ultrasonics sonochemistry·2026
Same journal

Ultrasound modified flaxseed protein-rice starch composite system for texture-modified soft gels: structural, functional, and swallowing properties.

Ultrasonics sonochemistry·2026
Same journal

Sustainable extraction of polyphenols from Pleurotus eryngii using ultrasound-assisted deep eutectic solvents with process optimization and biological activity.

Ultrasonics sonochemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 24, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.1K

Mechanisms underlying sonoporation: Interaction between microbubbles and cells.

Yanye Yang1, Qunying Li2, Xiasheng Guo1

  • 1Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China.

Ultrasonics Sonochemistry
|April 12, 2020
PubMed
Summary
This summary is machine-generated.

Smart drug delivery utilizes ultrasound-activated microbubbles to enhance drug delivery efficiency. This review explores the sonoporation mechanism, influencing factors, and clinical applications of this promising technology.

Keywords:
Cavitation activityMicrobubble-mediated drug deliverySonoporationUltrasound-activated bubble-cell interactions

More Related Videos

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.4K
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.6K

Related Experiment Videos

Last Updated: Dec 24, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.1K
Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.4K
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.6K

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Acoustic Medicine

Background:

  • Smart drug delivery aims for targeted therapeutic agent delivery.
  • Ultrasound-induced microbubble activity, known as sonoporation, is a key mechanism for enhanced cellular uptake.
  • Controllable drug delivery to specific body regions is a significant advancement.

Purpose of the Study:

  • To provide an overview of the microbubble-mediated sonoporation mechanism.
  • To identify and discuss factors impacting sonoporation outcomes.
  • To review the current progress and clinical considerations of sonoporation.

Main Methods:

  • Review of experimental and numerical studies on microbubble-cell interactions.
  • Analysis of parameters affecting sonoporation.
  • Synthesis of current research on clinical applications.

Main Results:

  • Sonoporation relies on ultrasound-activated mechanical forces from microbubble-cell interactions.
  • Outcomes are influenced by cavitation agents, cell properties, acoustic parameters, and micro-environment.
  • The review consolidates understanding of the sonoporation process.

Conclusions:

  • Microbubble-mediated sonoporation is a promising strategy for spatiotemporal-controllable drug delivery.
  • Understanding influencing factors is crucial for optimizing therapeutic outcomes.
  • Further research and development are needed for successful clinical translation.