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The Microbiome and Chronic Rhinosinusitis.

Do-Yeon Cho1, Ryan C Hunter2, Vijay R Ramakrishnan3

  • 1Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, 1155 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35233, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Immunology and Allergy Clinics of North America
|April 13, 2020
PubMed
Summary
This summary is machine-generated.

Chronic rhinosinusitis (CRS) involves persistent sinus inflammation. Research suggests that an altered sinus microbiome, or dysbiosis, may play a key role in CRS development and progression.

Keywords:
AnaerobeAnimal model of CRSChronic rhinosinusitisMicrobiomeMucin fermentationPseudomonasSinusitis

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Area of Science:

  • Microbiology
  • Immunology
  • Otolaryngology

Background:

  • Chronic rhinosinusitis (CRS) is characterized by persistent inflammation of the nasal cavity and paranasal sinuses.
  • Understanding the role of the sinus microbiome in CRS pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • This review explores the complex role of the sinus microbiota in both health and CRS.
  • It examines the implications of dysbiosis and microbial interactions in CRS.
  • The review also discusses considerations for investigating the sinus microbiome and developing preclinical models.

Main Methods:

  • Literature review of recent advancements in culture-independent molecular techniques.
  • Analysis of studies investigating sinus microbiota composition and function in CRS patients.
  • Discussion of preclinical models for studying CRS-associated microbiome alterations.

Main Results:

  • Advancements in molecular techniques have improved the understanding of sinus microbiota.
  • The dysbiosis hypothesis suggests that alterations in the sinus microbiome contribute to CRS.
  • Microbial interactions within the sinus environment are complex and implicated in CRS.

Conclusions:

  • The sinus microbiome plays a significant role in the health and disease of the upper airway.
  • Dysbiosis of the sinus microbiota is a key factor in CRS pathogenesis.
  • Future research should focus on preclinical models and further elucidate microbial interactions in CRS.