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Impact of Life-Context Factors on Chronic Rhinosinusitis 22-Item Sinonasal Outcomes Test: Systematic Review + Meta-Analysis.

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Topical Irrigations for Chronic Rhinosinusitis.

Victoria S Lee1

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, 1855 West Taylor Street, MC 648, Room 3.87, Chicago, IL 60611, USA.

Immunology and Allergy Clinics of North America
|April 13, 2020
PubMed
Summary
This summary is machine-generated.

Topical corticosteroid sprays and saline irrigations are key treatments for chronic rhinosinusitis, shifting focus from infection to inflammation. Further research is needed on corticosteroid effects and alternative therapies like antifungals and probiotics.

Keywords:
Chronic rhinosinusitisIrrigationsManuka honeySalineTopical antibioticsTopical antifungalsTopical steroidsTopical therapies

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Area of Science:

  • Otolaryngology
  • Inflammatory Diseases

Background:

  • Understanding of chronic rhinosinusitis (CRS) etiology has evolved from infection to inflammation.
  • Topical corticosteroid sprays and saline irrigations are now primary treatments for CRS.

Purpose of the Study:

  • To review current and emerging topical therapies for chronic rhinosinusitis.
  • To highlight areas requiring further research in CRS treatment.

Main Methods:

  • Literature review of topical treatments for chronic rhinosinusitis.
  • Analysis of current treatment mainstays and emerging therapies.

Main Results:

  • Topical corticosteroids and saline irrigations are mainstays, especially post-operatively.
  • Topical antibiotic use is limited to refractory cases.
  • Topical antifungals warrant further study for allergic fungal rhinosinusitis.
  • Biofilm-targeting therapies and probiotics are emerging areas of interest.

Conclusions:

  • Current topical treatments for CRS are effective but require ongoing research.
  • Further investigation into corticosteroid safety (hypothalamic-pituitary-adrenal axis suppression) is necessary.
  • Emerging therapies targeting biofilms and utilizing probiotics show promise for future CRS management.