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Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios
Nora Bruns1, Ann-Christin Stähling1, Sandra Greve1
1Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany.
Pediatrics and Neonatology
|April 13, 2020
Summary
Postnatal serum creatinine levels in preterm infants with preterm premature rupture of membranes (PPROM) are linked to amniotic fluid volume. Infants with anhydramnios show elevated creatinine, unlike those with normal fluid or oligohydramnios.
Area of Science:
- Neonatal physiology
- Perinatal medicine
- Pediatric nephrology
Background:
- Increased serum creatinine in preterm infants often lacks a clear cause.
- Amniotic fluid intake may influence postnatal creatinine levels.
- Preterm premature rupture of membranes (PPROM) provides a model to study this relationship.
Purpose of the Study:
- To investigate the correlation between postnatal serum creatinine in preterm infants and amniotic fluid volume.
- To assess if amniotic fluid intake, indicated by volume after PPROM, affects serum creatinine.
- To compare creatinine levels in infants with normal amniotic fluid, oligohydramnios, and anhydramnios.
Main Methods:
- Retrospective study of 74 preterm infants with PPROM > 48 hours.
- Serum creatinine measured at days 2-5, 10-17, and 26-33 of life.
- Comparison of creatinine levels based on intrauterine amniotic fluid volume (normal, oligohydramnios, anhydramnios).
Main Results:
- Serum creatinine levels were similar across groups at days 2-5 and 10-17.
- Creatinine decreased significantly from days 2-5 to 26-33 in infants with normal fluid and oligohydramnios.
- On day 26-33, infants with anhydramnios had significantly higher creatinine levels compared to the other groups.
Conclusions:
- Postnatal serum creatinine at day 26-33 is elevated in preterm infants with PPROM-induced anhydramnios.
- Oligohydramnios does not appear to significantly elevate late-term postnatal creatinine.
- Amniotic fluid volume post-PPROM is a relevant factor for late-term serum creatinine levels in preterm infants.
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