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Shared genetic background between children and adults with attention deficit/hyperactivity disorder
Paula Rovira1,2, Ditte Demontis3,4,5, Cristina Sánchez-Mora1,2,6,7
1Psychiatric Genetics Unit, Group of Psychiatry, Mental Health, and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
Summary
Common genetic variants contribute to attention deficit/hyperactivity disorder (ADHD) across the lifespan. This study confirms ADHD is a neurodevelopmental disorder with shared genetic underpinnings from childhood through adulthood.
Area of Science:
- Neurogenetics
- Developmental Psychiatry
Background:
- Attention deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a high persistence rate into adulthood.
- The genetic architecture influencing ADHD's developmental trajectory remains largely unknown.
Purpose of the Study:
- To investigate the contribution of common genetic variants to ADHD risk across the lifespan.
- To compare the genetic background of childhood ADHD and persistent adult ADHD.
Main Methods:
- Conducted meta-analyses of genome-wide association studies on childhood ADHD and persistent adult ADHD.
- Analyzed a combined sample of 17,149 cases and 32,411 controls.
- Examined genetic correlations with related traits and disorders.
Main Results:
- Identified nine new independent genetic loci associated with ADHD.
- Confirmed a shared genetic contribution of common variants to ADHD in both children and adults.
- Observed consistent genetic correlations across different age groups and with other traits.
Conclusions:
- Persistent adult ADHD is a neurodevelopmental disorder with a shared genetic basis.
- The findings support a lifespan perspective on the genetic architecture of ADHD.
- Common genetic variants play a significant role in ADHD risk throughout development.
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