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Updated: Dec 24, 2025

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
Published on: September 18, 2021
Memory-related process in physiological status and alzheimer's disease
Seyedeh Nahid Fotuhi1, Mohammad Khalaj-Kondori2, Mohammad Ali Hoseinpour Feizi1
1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Abstract:
Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer's disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline-concluding that AD destroys memory formation related-pathways.
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