Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.4K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Approach to Engineering Tomato Spotted Wilt Virus Infectious Clones by Disarming Key Nodes in Anti-Viral Defenses.

Molecular plant-microbe interactions : MPMI·2026
Same author

False positive serum vascular endothelial growth factor-D in a patient with Birt-Hogg-Dubé syndrome.

Respiratory medicine case reports·2026
Same author

A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Immediate versus conventional loading implants with fixed prosthesis - A clinical and radiological study.

Bioinformation·2026
Same author

Diffuse Alveolar Hemorrhage in Lymphangioleiomyomatosis.

Chest·2026
Same author

Assessment of the Accuracy of Clear Aligner Therapy for Maxillary Expansion: A Prospective Clinical Study.

Clinical, cosmetic and investigational dentistry·2026

Related Experiment Video

Updated: Dec 24, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.4K

Pulmonary Langerhans Cell Histiocytosis.

Brian Shaw1, Michael Borchers2,3, Dani Zander4

  • 1Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.

Seminars in Respiratory and Critical Care Medicine
|April 13, 2020
PubMed
Summary

Pulmonary Langerhans cell histiocytosis (PLCH) is an inflammatory myeloid neoplasm linked to smoking. Identifying MAPK pathway mutations offers hope for targeted therapies and biomarkers for this variable lung disease.

More Related Videos

Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells
09:33

Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells

Published on: April 5, 2017

18.0K
Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

9.6K

Related Experiment Videos

Last Updated: Dec 24, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.4K
Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells
09:33

Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells

Published on: April 5, 2017

18.0K
Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

9.6K

Area of Science:

  • Pulmonary Medicine
  • Oncology
  • Genetics

Background:

  • Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease.
  • It is strongly associated with cigarette smoke exposure.
  • Recent findings identify activating mutations in the mitogen-activated protein kinase (MAPK) pathway in PLCH, classifying it as an inflammatory myeloid neoplasm.

Purpose of the Study:

  • To review the current understanding of PLCH.
  • To discuss its molecular pathogenesis, clinical manifestations, and treatment.
  • To highlight future directions in biomarker and targeted therapy development.

Main Methods:

  • Literature review of PLCH.
  • Analysis of recent genetic and clinical studies.
  • Synthesis of information on pathogenesis, clinical course, and treatment.

Main Results:

  • PLCH is an inflammatory myeloid neoplasm driven by MAPK pathway mutations.
  • Clinical presentation and prognosis are highly variable, with potential for spontaneous resolution or progression.
  • Extrapulmonary involvement can occur, affecting the skeletal system, skin, or central nervous system (e.g., diabetes insipidus).

Conclusions:

  • Smoking cessation is the primary treatment for PLCH, often leading to disease stabilization or regression.
  • Understanding the molecular drivers of PLCH opens avenues for developing specific biomarkers and targeted therapies.
  • Further research is needed to fully elucidate the disease course and optimize management strategies.