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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

Amyloid Fibrils

Amyloid Fibrils

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

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Related Experiment Video

Updated: Dec 24, 2025

Methods for Detecting Cytotoxic Amyloids Following Infection of Pulmonary Endothelial Cells by Pseudomonas aeruginosa

Methods for Detecting Cytotoxic Amyloids Following Infection of Pulmonary Endothelial Cells by Pseudomonas aeruginosa

Published on: July 12, 2018

Amyloid in the Lung.

Misbah Baqir¹, Anja C Roden², Teng Moua¹

¹Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Seminars in Respiratory and Critical Care Medicine

|April 13, 2020

Summary

This summary is machine-generated.

Pulmonary amyloidosis involves abnormal protein deposits in the lungs, often linked to AL and AA amyloid subtypes. Prognosis depends on overall organ involvement, with multisystemic disease posing the highest risk.

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Area of Science:

Pulmonology
Pathology
Radiology

Background:

Amyloidosis is characterized by misfolded protein deposition, leading to organ dysfunction.
Pulmonary manifestations are nonspecific and associated with amyloid protein subtypes like AL and AA.
Clinical presentation often reflects other organ involvement more than lung-specific symptoms.

Purpose of the Study:

To summarize the pulmonary manifestations of amyloidosis.
To describe associated radiologic findings and clinical implications.
To discuss the prognostic factors in pulmonary amyloidosis.

Main Methods:

Review of literature on pulmonary amyloidosis.
Analysis of radiologic findings in affected patients.
Correlation of clinical signs with organ involvement.

Main Results:

Radiologic findings include infiltrates, nodules, cysts, and tracheobronchial abnormalities.
Lymphadenopathy, calcification, and pleural effusions may also be present.
Therapy is directed by clinical signs, often secondary to systemic diseases.

Conclusions:

Pulmonary involvement in amyloidosis is variable and nonspecific.
Prognosis is largely determined by the extent of systemic organ involvement.
Multisystemic disease carries the highest morbidity and poorest long-term outlook.