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Clinical factors affecting left ventricular end-diastolic pressure in patients with acute ST-segment elevation

Xia Zhou1, Mingming Lei1, Donghui Zhou1

  • 1Department of Cardiology, the 4th Affiliated Hospital of China Medical University, Shenyang 110032, China.

Annals of Palliative Medicine
|April 14, 2020
PubMed

Insights

Elevated left ventricular end-diastolic pressure (LVEDP) in ST-segment elevation myocardial infarction (STEMI) patients is linked to worse outcomes, including heart failure and increased mortality. This pressure impacts coronary artery disease severity and ventricular function.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Left ventricular end-diastolic pressure (LVEDP) is associated with outcomes in ischemic heart diseases.
  • Investigating LVEDP patterns and influencing factors in acute ST-segment elevation myocardial infarction (STEMI) is crucial.

Purpose of the Study:

  • To analyze left ventricular end-diastolic pressure (LVEDP) patterns in STEMI patients.
  • To identify factors affecting LVEDP in STEMI patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • 515 STEMI patients undergoing immediate PCI were grouped by LVEDP (≤15 mmHg vs. >15 mmHg).
  • Measurements included left ventricular ejection fraction (EF%), ventricular structure, myocardial necrosis markers, and coronary angiography.
  • Blood samples were collected pre- and post-PCI.

Main Results:

  • Higher LVEDP group showed more severe coronary artery disease, impaired ventricular function (lower EF%), and higher heart failure rates.
  • LVEDP correlated positively with markers of necrosis, ventricular dilation, and cardiac strain (e.g., troponin T, NT-proBNP).
  • LVEDP correlated negatively with glomerular filtration rate and EF%.

Conclusions:

  • Elevated LVEDP in STEMI patients indicates a higher risk of heart failure and mortality.
  • LVEDP is associated with the severity of the infarction-related artery and adverse ventricular remodeling.
Abstract

Keywords:
Left ventricular end-diastolic pressure (LVEDP)ST-segment elevationacute myocardial infarctioninfarction related artery distributionpercutaneous coronary intervention (PCI)ventricular diastolic function

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