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Simple, Affordable, and Modular Patterning of Cells using DNA
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Patterns in soft and biological matters.

Dmitri V Alexandrov1, Andrey Yu Zubarev1

  • 1Laboratory of Multi-Scale Mathematical Modeling, Department of Theoretical and Mathematical Physics, Ural Federal University, Ekaterinburg 620000, Russian Federation.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|April 14, 2020
PubMed
Summary
This summary is machine-generated.

This research explores pattern formation in soft and biological materials, revealing how internal structures influence material properties and behavior. Understanding these patterns is key for developing advanced therapies and novel materials.

Keywords:
biophysical systemsheterogeneous materialsmetastable and non-equilibrium statespatternsphase transformationssoft matter

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Area of Science:

  • Physics
  • Materials Science
  • Biophysics

Background:

  • Internal heterogeneous patterns significantly impact the macroscopic properties and behavior of diverse soft physical systems, including organic and inorganic materials.
  • Understanding pattern morphology and evolution is crucial for both natural and manufactured materials, as well as biological tissues.

Purpose of the Study:

  • To investigate the theoretical, computational, and experimental aspects of internal pattern formation, morphology, and evolution in soft matter.
  • To explore non-equilibrium patterns arising from transport phenomena, chemical reactions, external fields, and noise.
  • To advance scientific understanding for progressive therapies, particularly in cancer and insult treatment.

Main Methods:

  • Utilizing modern computer modeling, statistical physics, heat and mass transfer principles, statistical hydrodynamics, and nonlinear dynamics.
  • Employing experimental methods to study pattern evolution under various conditions.
  • Focusing on systems with complex internal structures and stochastic dynamics.

Main Results:

  • Detailed examination of non-equilibrium patterns generated by hydrodynamic flow, chemical reactions, and external physical fields (magnetic, electrical, thermal).
  • Analysis of pattern formation in biological systems, including drug transport and blood flow dynamics.
  • Investigation into the influence of internal structures on static, dynamic magnetic, and mechanical properties.

Conclusions:

  • The study highlights the critical role of internal patterns in dictating material properties and behavior across various soft and biological systems.
  • Findings provide a foundation for developing advanced therapeutic strategies, such as magnetic hyperthermia and targeted drug delivery.
  • The research underscores the importance of interdisciplinary approaches combining physics, computation, and experimentation to understand complex pattern dynamics.