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A trial of lacosamide for benign convulsions with gastroenteritis
Shingo Numoto1, Hirokazu Kurahashi2, Hideyuki Iwayama2
1Department of Pediatrics, Aichi Medical University, Nagakute, Aichi, Japan; Department of Pediatrics, Daiyukai General Hospital, Ichinomiya, Aichi, Japan.
Abstract:
Benign convulsions with gastroenteritis are characterized by a cluster of seizures. Sodium channel blockers are efficacious. We prescribed lacosamide, a new channel blocker, for five patients. Patient age ranged from 17 to 33 months; all five experienced 1-4 generalized convulsions persisting for 30-120 s. One patient exhibited a transient splenial lesion on head magnetic resonance imaging. All received one dose (2 mg/kg) of lacosamide. The convulsions ceased, and no adverse drug effect was noted. A single dose of lacosamide was effective and well-tolerated in five patients with benign convulsions with gastroenteritis.
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