Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liver Transplantation in Patients With Cystic Fibrosis: 30 Years of Experience in Australia and New Zealand.

ANZ journal of surgery·2026
Same author

Unraveling the impact of common medications on biomarker patterns in Alzheimer's disease and mild cognitive impairment.

Journal of Alzheimer's disease reports·2026
Same author

Midbrain <i>Tet1</i> dosage defines inter-individual binge-eating susceptibility.

bioRxiv : the preprint server for biology·2026
Same author

Salivary metabolomics for early detection of vascular contributions to cognitive impairment and dementia: Exploring microbiome dysbiosis and sex differences.

Journal of Alzheimer's disease : JAD·2026
Same author

Gas-depleted planet formation occurred in the four-planet system around the red dwarf LHS 1903.

Science (New York, N.Y.)·2026
Same author

A Sensitized ENU Mutagenesis Screen for Thrombosis Modifiers Identifies Suppressor Variants in Non-mutagenized Parental Generations Due to Antithrombotic Selective Pressures.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Dec 24, 2025

Intracerebroventricular Injection of Amyloid-&#946; Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
08:01

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits

Published on: March 16, 2016

44.0K

Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice.

George D Wilson1, Thomas G Wilson1, Alaa Hanna1

  • 1Radiation Oncology Department, Beaumont Health, Royal Oak, MI, USA.

Journal of Alzheimer'S Disease : JAD
|April 14, 2020
PubMed
Summary

Low-dose radiation therapy significantly reduced amyloid-beta plaques and tau pathology in a mouse model of Alzheimer's disease. These findings suggest radiation may be a potential therapeutic strategy for neurodegenerative disorders.

Keywords:
Amyloid-βradiationreductiontau

More Related Videos

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of A&#946; and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
06:22

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

3.9K
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
08:16

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

18.9K

Related Experiment Videos

Last Updated: Dec 24, 2025

Intracerebroventricular Injection of Amyloid-&#946; Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
08:01

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits

Published on: March 16, 2016

44.0K
A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of A&#946; and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
06:22

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

3.9K
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
08:16

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

18.9K

Area of Science:

  • Neuroscience
  • Radiology
  • Pathology

Background:

  • Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) plaques and tau tangles.
  • Previous studies indicated low-dose irradiation may reduce Aβ and improve cognition in certain AD mouse models.

Purpose of the Study:

  • To investigate the effects of low-dose external beam ionizing irradiation on Aβ plaques and tau pathology in the 3xTg-AD mouse model.
  • To assess the correlation between Aβ plaque burden and tau staining after irradiation.

Main Methods:

  • Age-matched 3xTg-AD mice were hemibrain-irradiated with 5 fractions of 2 Gy.
  • Mice were sacrificed 8 weeks post-treatment.
  • Aβ and tau were quantified using immunohistochemistry and Definiens Tissue Studio image analysis.

Main Results:

  • A significant reduction in Aβ plaque burden was observed in irradiated hemibrains.
  • A significant reduction in tau staining was also noted.
  • Aβ plaque burden and tau staining were significantly correlated.

Conclusions:

  • Low-dose irradiation effectively reduced both Aβ plaques and tau pathology in the 3xTg-AD mouse model.
  • These preliminary findings support the potential therapeutic benefit of low-dose radiation for Alzheimer's disease.
  • Further research is warranted to explore radiation as a treatment for AD.