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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Related Experiment Video

Updated: Dec 24, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

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Bioinformatics Analysis for Multiple Gene Expression Profiles in Sepsis.

Jianhua Zhai1, Anlong Qi1, Yan Zhang1

  • 1Department of Emergency, Tianjin Medical University General Hospital, Tianjin, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|April 14, 2020
PubMed
Summary
This summary is machine-generated.

This study identified key genes like MYC, TRIM25, and RNF4 as potential biomarkers for sepsis progression and diagnosis using bioinformatics analysis of gene expression data.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Immunology

Background:

  • Sepsis progression involves complex molecular changes.
  • Identifying reliable biomarkers is crucial for early diagnosis and treatment.

Purpose of the Study:

  • To screen key biomarkers for sepsis progression using bioinformatics.
  • To evaluate the diagnostic value of identified genes.

Main Methods:

  • Downloaded and analyzed microarray datasets of blood and neutrophils from sepsis patients.
  • Identified differentially expressed genes (DEGs) and constructed protein-protein interaction (PPI) networks.
  • Performed functional enrichment analysis and receiver operating characteristic (ROC) analysis.

Main Results:

  • Identified thousands of DEGs in blood and neutrophils across sepsis and septic shock.
  • Discovered TRIM25 and MYC as hub genes in blood, with high diagnostic value (AUCs 0.843-0.912).
  • Identified RNF4 as a hub gene in neutrophils with high diagnostic value (AUC 0.909).

Conclusions:

  • TRIM25, MYC, and RNF4 are key genes associated with sepsis progression.
  • These genes demonstrate significant diagnostic potential for sepsis and septic shock.