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Protein tyrosine phosphatase nonreceptor type 22 gene polymorphism in alopecia areata: Does it have an association
Wafaa Ahmed Shehata1, Alaa Maraee1, Heba Kamal2
1Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.
Background:
Alopecia areata is a condition involving hair loss from certain or all areas of the body. It has been considered as an immune-mediated disease, characterized by the infiltration of CD4+ and CD8+ lymphocytes in the hair follicles.
Aim Of The Study:
The study aimed to assess whether protein tyrosine phosphatase nonreceptor type 22 gene single nucleotide polymorphism 1858C/T has any relationship with alopecia areata in Egyptian patients and whether it is associated with disease severity or not.
Subjects And Methods:
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) C1858T gene polymorphism was identified using polymerase chain reaction-restriction fragment length polymorphism analysis technique in 60 patients suffering from alopecia areata and 30 age- and sex-matched healthy controls. Disease severity was assessed using SALT score.
Results:
CT and TT genotypes were significantly higher in the patients' group (P = .005), OR = 4.38 95% CI [1.48-12.96], with significant statistical predominance of T allele in patients, P = .003, OR = 3.86, 95% CI [1.52-9.77]. There was also a positive significant relationship between protein tyrosine phosphatase nonreceptor type 22 genotype CT and SALT score.
Conclusion:
PTPN22 1858T allele is associated with the development and severity of alopecia areata in Egyptians.
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