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Fragile site in chromosome 12 in a patient with two miscarriages
G Stetten1, B Sroka, M Norbury-Glaser
1Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland 21205.
American Journal of Medical Genetics
|November 1, 1988
Abstract:
A heritable fragile site at 12q13 is described in lymphocytes from a woman with a history of multiple miscarriage. The fragile site was not typically folate-sensitive, being expressed in standard medium. The presence of this fragile site may have led to meiotic chromosome breakage and consequent infertility.