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Updated: Dec 24, 2025
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic compounds from the stems of Diospyros ehretioides and their bioactivity
Pattamaporn Wosawat1, Thanaset Senawong2, Nattawut Suchaichit3
1Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Abstract:
A new (naphthalenyl)methyl acetate, (1,4,5-trimethoxynaphthalen-2-yl)methyl acetate (1) and (±)-4,5-dihydroxy-2-methyltetralone (2) were isolated together with five lupane triterpenes (3-7), naphthoquinone derivatives (8-13), coumarins (14 and 15) and a vanillic acid (16) from the stems of Diospyros ehretioides. Their structures were established through spectroscopic analysis, IR, 1D and 2D NMR. Both 1 and 2 displayed significant cytotoxicity against three cancer cell lines including HeLa, HCT116 and MCF-7, with IC50 values in the range of 5.05-15.90 µg/mL, while 16 exhibited moderate cytotoxicity against HeLa and HCT116 cell lines and was not toxic to Vero cells.
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