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The Oncogenic Functions of Insulin-like Growth Factor 2 mRNA-Binding Protein 3 in Human Carcinomas

Peng-Fei Wang1, Xiaoyu Wang1, Min Liu1

  • 1Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin, 150081, China.

Current Pharmaceutical Design
|April 14, 2020
PubMed

Insights

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) promotes cancer development by interacting with RNAs and proteins. High IGF2BP3 levels indicate advanced cancer and suggest it as a diagnostic marker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is crucial for embryonic development.
  • IGF2BP3 expression is restricted in adult tissues but elevated in various cancers.

Purpose of the Study:

  • To review the role of IGF2BP3 in cancer progression.
  • To explore IGF2BP3's potential as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on IGF2BP3, RNA, and protein interactions in cancer.
  • Analysis of IGF2BP3's expression patterns and clinical significance.

Main Results:

  • IGF2BP3 promotes cancer cell proliferation, metastasis, and inhibits apoptosis.
  • High IGF2BP3 expression correlates with advanced cancer stages and poor patient survival.

Conclusions:

  • IGF2BP3 is a key driver of cancer progression through interactions with non-coding RNAs and proteins.
  • IGF2BP3 shows promise as a biomarker for cancer diagnosis and staging.
  • Targeting IGF2BP3 with drugs or antibodies offers a potential new cancer therapy.
Keywords:
IGF2BP3biomarkercarcinomafunctionmalignancymechanisms.

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