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Updated: Dec 24, 2025

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Diagnosis and Treatment of Oral Venous Malformation in a Child
Vitor Bonetti Valente1, Giseli Mitsuy Kayahara, Glauco Issamu Miyahara
1Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil.
Abstract:
Venous malformations (VMs) are congenital disorders that constitute about 40% of all vascular anomalies. These lesions do not regress spontaneously and may increase in size during childhood. The case of a 10-year-old girl with an extensive oral VM is reported. Intraoral examination revealed the presence of purplish nodules in the alveolar mucosa and gingiva from anterior maxilla. Doppler ultrasound showed a well-defined hypoechoic image and increased vascularization with low blood flow for the alveolar mucosa lesion. The patient was submitted to intralesional injections of the ethanolamine oleate/mepivacaine sclerosing solution. After four sessions, there was a significant reduction of the lesions. However, the patient abandoned the treatment and the oral VM grew progressively. After 1 year, sclerotherapy was resumed and performed weekly. After 10 session of sclerotherapy, the oral VM totally regressed. The childhood is a critical period for oral VM growth. Doppler ultrasound and sclerotherapy can be effective for the management of extensive lesions in children.
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