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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Dec 24, 2025

Minimally-invasive Technique for Injection into Rat Optic Nerve

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

Optic Nerve Regeneration: How Will We Get There?

Kimberly K Gokoffski¹, Phillip Lam, Basheer F Alas

¹Department of Ophthalmology, Roski Eye Institute, University of Southern California, Los Angeles, California.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society

|April 14, 2020

Summary

This summary is machine-generated.

Restoring vision in optic neuropathies needs to save or replace retinal ganglion cells (RGCs). This review covers barriers and progress in cell-replacement therapies and stem cell treatments for optic nerve regeneration.

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Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

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Last Updated: Dec 24, 2025

Minimally-invasive Technique for Injection into Rat Optic Nerve

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

Transconjunctival Approach for Injection into the Rat Optic Nerve

Transconjunctival Approach for Injection into the Rat Optic Nerve

Published on: April 4, 2025

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

Area of Science:

Ophthalmology
Neuroscience
Regenerative Medicine

Background:

Advanced optic neuropathies cause vision loss by damaging retinal ganglion cells (RGCs).
Restoration strategies focus on preserving existing RGCs or replacing those that are lost.

Purpose of the Study:

To review barriers to cell-replacement strategies for optic nerve regeneration.
To provide an update on progress in overcoming these barriers.
To update on current stem cell-based therapies for optic nerve regeneration.

Main Methods:

Literature review of scientific publications.
Analysis of cell-replacement and stem cell therapy research.

Main Results:

Significant barriers exist for cell-replacement strategies in optic nerve regeneration.
Progress is being made in developing these strategies.
Current stem cell therapies for optic nerve regeneration are under active investigation.

Conclusions:

Neuro-regenerative and cell-transplantation strategies are advancing.
Collaboration between researchers and clinicians is crucial.
Identifying suitable candidates for these therapies is a key future step.