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Perinatal HIV-1 Infection in an Extremely Low Birth Weight Infant
Roukaya Al Hammoud1, Chiamaka Aneji, Gloria Heresi
1From the Pediatric Infectious Diseases Division, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas.
Insights
Treating extremely premature infants with HIV is challenging. Early antiretroviral therapy is crucial to manage HIV reservoir size and disease progression in these vulnerable infants.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pediatric HIV
Background:
- Limited guidance exists for managing extremely premature infants with HIV infection.
- Delayed antiretroviral therapy (ART) initiation can negatively impact HIV reservoir size and disease progression.
- Perinatal HIV-1 transmission poses significant risks to extremely low birth weight infants.
Abstract:
There is limited guidance on how to treat extremely premature infants with HIV infection. This can lead to delay of antiretroviral therapy initiation adversely affecting magnitude of HIV reservoir and disease progression. We report perinatal HIV-1 infection in an extremely low birth weight infant born at 24 5/7 weeks of gestation. Treatment challenges, viral dynamics and clinical outcomes are described.
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