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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Updated: Dec 24, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Association between CD24 Ala/Val polymorphism and multiple sclerosis risk: A meta analysis.

Wan Yang1,2,3, Wang Zhou4, Bo-Kang Zhang1,2,3

  • 1Department of Anesthesiology, Anhui Provincial Cancer Hospital, Hefei.

Medicine
|April 14, 2020
PubMed
Summary

The CD24 Val allele is linked to increased multiple sclerosis (MS) risk, particularly in Asian populations. Further research is needed to understand this CD24 Ala/Val polymorphism

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Area of Science:

  • Genetics
  • Immunology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Genetic factors play a role in MS susceptibility.
  • The CD24 gene and its polymorphisms are investigated for potential links to MS.

Purpose of the Study:

  • To investigate the association between the CD24 Ala/Val polymorphism and the risk of developing multiple sclerosis.
  • To synthesize evidence from existing case-control studies through a meta-analysis.

Main Methods:

  • A systematic literature search was conducted across major scientific databases (PubMed, Web of Science, Embase, etc.).
  • A meta-analysis of seven case-control studies was performed using STATA 11.0.
  • Pooled odds ratios and 95% confidence intervals were calculated to assess the association.

Main Results:

  • The meta-analysis revealed a significant association between the CD24 Ala/Val polymorphism and MS susceptibility.
  • Stratified analysis indicated a significant association in Asian populations.
  • No significant association was observed in European populations.

Conclusions:

  • The CD24 Val allele is associated with an elevated risk of multiple sclerosis.
  • The CD24 Ala/Val polymorphism may contribute to MS pathogenesis, particularly in certain ethnic groups.
  • Larger-scale population studies are recommended to further elucidate the role of this polymorphism in MS.