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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
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Long non-coding RNA molecules in tuberculosis.

Hadis Fathizadeh1, Seyed Mohammad Gheibi Hayat2, Sounkalo Dao3

  • 1Department of Microbiology and immunology, Kashan University of Medical Sciences, Kashan, Iran.

International Journal of Biological Macromolecules
|April 14, 2020
PubMed
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Long non-coding RNAs (lncRNAs) show promise as biomarkers and therapeutic targets for tuberculosis (TB). Understanding lncRNA expression patterns in TB infection is crucial for developing new diagnostic and treatment strategies.

Keywords:
Long non-coding RNAMycobacterium tuberculosisTuberculosis infection

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Area of Science:

  • Molecular Biology
  • Genomics
  • Infectious Diseases

Background:

  • Tuberculosis (TB) remains a leading cause of death globally, with challenges in early detection and treatment.
  • Gene expression dysregulation is implicated in TB pathogenesis.
  • Long non-coding RNAs (lncRNAs) are emerging regulators of gene expression with roles in various cellular processes.

Purpose of the Study:

  • To review current findings on lncRNA expression patterns in tuberculosis.
  • To explore the role of lncRNAs in the tuberculosis infection process.
  • To highlight the potential of lncRNAs as biomarkers and therapeutic targets for TB.

Main Methods:

  • Literature review of studies investigating lncRNAs in tuberculosis.
  • Analysis of lncRNA expression profiles in TB patients and models.
  • Examination of the functional roles of specific lncRNAs in Mycobacterium tuberculosis infection.

Main Results:

  • Dysregulation of specific lncRNAs is observed in tuberculosis.
  • lncRNAs are involved in regulating gene expression critical to TB pathogenesis.
  • Altered lncRNA expression correlates with disease status and progression.

Conclusions:

  • lncRNAs represent promising novel molecular biomarkers for TB diagnosis and prognosis.
  • Targeting lncRNAs may offer new therapeutic strategies for tuberculosis.
  • Further research into lncRNA functions in TB is warranted.