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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

Qing Ye1, Bili Wang1, Jianhua Mao1

  • 1National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, No 3333, Binsheng Road, Hangzhou 310052, China.

The Journal of Infection
|April 14, 2020
PubMed

Insights

Cytokine storm, an overactive immune response, can cause severe illness and high mortality in COVID-19 patients. This review examines the mechanisms and treatments for this inflammatory storm to guide clinical practice.

Area of Science:

  • Immunology
  • Virology
  • Critical Care Medicine

Background:

  • Cytokine storm is a severe immune overreaction to stimuli.
  • Its complex pathogenesis leads to rapid progression and high mortality.
  • COVID-19 patients experiencing severe deterioration are often linked to cytokine storms.

Purpose of the Study:

  • To review the occurrence mechanisms of COVID-19-induced cytokine storm.
  • To explore effective treatment strategies for this condition.
  • To offer medication guidance for clinical management.

Main Methods:

  • Literature review of existing studies on cytokine storm and COVID-19.
  • Analysis of the pathogenesis and clinical manifestations.
  • Synthesis of current and emerging treatment options.

Main Results:

  • Cytokine storm pathogenesis involves complex immune dysregulation.
  • Early identification and intervention are crucial for managing severe COVID-19.
  • Various therapeutic approaches are being investigated, including anti-cytokine therapies.

Conclusions:

  • Understanding cytokine storm mechanisms is vital for COVID-19 treatment.
  • Targeted therapies may mitigate the severity of the inflammatory response.
  • Further research is needed to optimize treatment protocols for cytokine storm in COVID-19.

Keywords:
2019-nCoVCoronavirusCytokine stormImmunomodulationSARS-CoV-2

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