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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Association between increased plasma ceramides and chronic kidney disease in patients with and without ischemic heart

A Mantovani1, G Lunardi2, S Bonapace3

  • 1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, 37126 Verona, Italy.

Diabetes & Metabolism
|April 14, 2020
PubMed

Insights

Plasma ceramide levels are elevated in patients with chronic kidney disease (CKD). These findings hold true even when accounting for heart disease and diabetes, suggesting ceramides as potential biomarkers for CKD.

Area of Science:

  • Biochemistry
  • Nephrology
  • Cardiology

Background:

  • Plasma ceramides are elevated in patients with ischemic heart disease (IHD).
  • The relationship between plasma ceramides and chronic kidney disease (CKD) is not well-established.
  • Shared risk factors exist for IHD and CKD.

Purpose of the Study:

  • To investigate whether plasma ceramide levels are increased in patients with CKD.
  • To determine the association between plasma ceramides and CKD, independent of other cardiovascular risk factors.

Main Methods:

  • Measured six specific plasma ceramide concentrations in 415 middle-aged individuals.
  • Defined CKD based on estimated glomerular filtration rate (e-GFR) and urinary albumin-to-creatinine ratio.
  • Analyzed associations after adjusting for multiple cardiovascular risk factors.

Main Results:

  • Patients with CKD exhibited significantly higher levels of all six measured plasma ceramides compared to those without CKD.
  • CKD remained significantly associated with elevated plasma ceramides after adjusting for BMI, smoking, hypertension, diabetes, IHD, LDL-cholesterol, hs-CRP, and lipid-lowering medication use.
  • Advanced CKD stages and abnormal albuminuria were independently associated with increased plasma ceramide levels.

Conclusions:

  • Elevated plasma ceramide levels are associated with CKD.
  • This association is independent of pre-existing IHD, diabetes, and other established cardiovascular risk factors.
  • Plasma ceramides may serve as potential biomarkers for CKD.
Abstract

Keywords:
CKDCardiovascular riskCeramidesKidney dysfunction

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