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Anti-Inflammatory Drugs as Anticancer Agents
Silvia Zappavigna1, Alessia Maria Cossu1,2, Anna Grimaldi1
1Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Targeting inflammation, a key factor in cancer development, offers promising strategies for cancer prevention and therapy. Anti-inflammatory agents, including novel ones, show significant potential in treating cancer by impacting tumor progression.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Inflammation is intrinsically linked to cancer, influencing tumor development and progression.
- Epidemiological studies confirm inflammation's role in cancer predisposition.
- Targeting inflammatory pathways presents a viable strategy for cancer prevention and treatment.
Purpose of the Study:
- To review the association between inflammation and cancer.
- To describe anti-inflammatory agents used in cancer therapy and their mechanisms.
- To highlight novel anti-inflammatory agents with anticancer activity.
Main Methods:
- Literature review of epidemiological and clinical studies.
- Analysis of anti-inflammatory agents and their impact on the tumor microenvironment.
- Focus on mechanisms of action and novel therapeutic agents.
Main Results:
- Anti-inflammatory agents, such as non-steroidal anti-inflammatory drugs (NSAIDs), can modulate the tumor microenvironment.
- These agents demonstrate potential in reducing cell migration and increasing apoptosis and chemo-sensitivity.
- Novel anti-inflammatory agents exhibit significant anticancer activity.
Conclusions:
- The link between inflammation and cancer is well-established.
- Anti-inflammatory agents are valuable in cancer therapy by targeting key molecular processes.
- Further research into novel anti-inflammatory agents holds promise for improved cancer treatment strategies.
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