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Trace Elements, PPARs, and Metabolic Syndrome.

Yujie Shi1, Yixin Zou1, Ziyue Shen1

  • 1State Key Laboratory of Natural Medicines and School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China.

International Journal of Molecular Sciences
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Trace elements impact metabolic syndrome (MetS) by influencing peroxisome proliferator-activated receptors (PPARs). Understanding this link, including circadian rhythms, is crucial for developing effective MetS treatments.

Keywords:
copperironmetabolic syndromeperoxisome proliferator-activated receptorsseleniumtrace elementszinc

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Area of Science:

  • Biochemistry
  • Metabolic Research
  • Nutritional Science

Background:

  • Metabolic syndrome (MetS) involves multiple metabolic dysfunctions like obesity, insulin resistance, and dyslipidemia.
  • Trace element imbalances are recognized as independent risk factors contributing to MetS development.
  • Peroxisome proliferator-activated receptors (PPARs) are key regulators linking trace elements and metabolic homeostasis.

Purpose of the Study:

  • To elucidate the molecular mechanisms connecting trace elements, PPARs, and the pathogenesis of MetS.
  • To highlight the role of PPARs in metabolic processes affected by trace elements.
  • To investigate the potential impact of circadian rhythms on trace element-PPAR interactions in MetS.

Main Methods:

  • Review of existing literature on trace elements, PPARs, and metabolic syndrome.
  • Analysis of experimental data showing effects of iron, zinc, and selenium on PPAR expression and activity.
  • Consideration of the influence of circadian rhythms on PPAR function.

Main Results:

  • Trace elements modulate PPARs: iron affects PPAR-α, zinc influences PPAR-α DNA binding, and selenium impacts PPAR-γ.
  • PPARs are involved in key metabolic processes such as adiposity and insulin sensitivity.
  • PPAR expression and activity exhibit circadian rhythmicity, potentially explaining clinical limitations of trace element therapies.

Conclusions:

  • Understanding the interplay between trace elements, PPARs, and MetS is critical for therapeutic advancements.
  • Further research into the chronopharmacological effects of trace elements on diurnal PPAR oscillations is warranted.
  • Investigating the circadian aspects of trace element-PPAR interactions may lead to improved MetS management strategies.