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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons.

Matilde Capi¹, Leda Marina Pomes¹, Giulia Andolina²

¹Department of Neurosciences, Mental Health & Sensory Organs (NESMOS), Sapienza University of Rome, 00185 Rome, Italy.

International Journal of Environmental Research and Public Health

|April 15, 2020

Summary

Persistent post-traumatic headache (PPTH) shares similarities with migraine but follows mild or moderate traumatic brain injury (mTBI). Migraine treatments are effective for PPTH, despite differing underlying brain mechanisms.

Keywords:

PTTH drugs migraine pathophysiology persistent post-traumatic headache traumatic-brain injury

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Area of Science:

Neuroscience
Neurology
Headache Medicine

Background:

Persistent post-traumatic headache (PPTH) and migraine are clinically similar, often distinguished by a history of mild or moderate traumatic brain injury (mTBI).
Understanding the distinct brain alterations and biochemical pathways in PPTH is crucial for effective management.

Purpose of the Study:

To delineate the differences in brain activity and biochemical cascades between concussion-related headaches and migraine.
To evaluate the efficacy and safety of current therapeutic interventions for PPTH.

Main Methods:

Systematic review of studies adhering to the International Classification of Headache Disorder (ICHD) criteria.
Analysis of neuroimaging data focusing on functional connectivity and neuro-metabolic changes.

Main Results:

Significant differences in static functional connectivity (sFC) and dynamic functional connectivity (dFC) were observed between PPTH and migraine.
Neuro-metabolic changes following traumatic brain injury are linked to the development and pathophysiology of PPTH.
These findings suggest distinct pathophysiological mechanisms underlying PPTH.

Conclusions:

Despite differing underlying mechanisms, treatments effective for common migraine demonstrate efficacy in patients with PPTH.
This highlights a potential therapeutic overlap and the need for further research into PPTH management.