Related Experiment Video
Updated: Dec 24, 2025
07:53
Bioindication Testing of Stream Environment Suitability for Young Freshwater Pearl Mussels Using In Situ Exposure Methods
Published on: September 5, 2018
7.6K
15O-Water PET MPI: Current Status and Future Perspectives
Teemu Maaniitty1, Juhani Knuuti1, Antti Saraste2
1Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland.
Seminars in Nuclear Medicine
|April 15, 2020
Summary
15O-water Positron Emission Tomography (PET) accurately quantifies myocardial blood flow (MBF) and myocardial flow reserve (MFR). This imaging technique effectively detects coronary artery stenosis and provides prognostic information for patients with coronary artery disease (CAD).
Area of Science:
- Nuclear Medicine
- Cardiology
- Radiochemistry
Background:
- Myocardial perfusion imaging using 15O-water Positron Emission Tomography (PET) is established for quantitative myocardial blood flow (MBF) and myocardial flow reserve (MFR) assessment.
- Advancements in PET scanner and software technology allow for precise global and regional MBF quantification in clinical settings.
Purpose of the Study:
- To review the fundamental principles of MBF measurement utilizing 15O-water PET.
- To synthesize findings from clinical studies evaluating 15O-water PET in the diagnosis of obstructive coronary artery disease (CAD).
Main Methods:
- Quantitative analysis of myocardial blood flow (MBF) and myocardial flow reserve (MFR) using 15O-water Positron Emission Tomography (PET).
- Comparison of PET-derived MBF/MFR with invasive fractional flow reserve (FFR) measurements for detecting significant coronary artery stenosis.
Main Results:
- Reduced stress MBF or MFR measured by 15O-water PET demonstrates high accuracy in identifying hemodynamically significant coronary artery stenosis.
- MBF and MFR values derived from 15O-water PET offer significant prognostic value regarding mortality and myocardial infarction risk.
- Clinical implementation of 15O-water PET for CAD evaluation is feasible and aids in guiding revascularization decisions.
Conclusions:
- 15O-water PET is a validated, quantitative tool for assessing myocardial blood flow and flow reserve.
- This technique accurately detects obstructive coronary artery disease and provides crucial prognostic information.
- Clinical application of 15O-water PET facilitates management strategies for patients with suspected or known CAD.
Related Concept Videos
01:23States of Water
55.7K
Water exists in any one of the three classical states: solid (ice), liquid (water), and gas (steam or water vapor). The state of water depends on i) the intermolecular forces that draw molecules together and ii) the kinetic energy that leads to movements that pull them apart.
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
55.7K
01:26Regulation of Water Output
1.9K
The human body predominantly expels water through the urinary system. On average, an individual generates around 1.5 liters of urine each day. This amount can fluctuate based on how well a person is hydrated, but a critical minimum quantity of urine must be produced to ensure the body's proper functioning. Daily, the kidneys remove 600 to 1200 milliosmoles of dissolved substances, effectively excreting excess minerals and water-soluble toxins such as creatinine, urea, and uric acid from the...
1.9K
01:19Quality of Water
440
In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
440
01:14Testing Water Quality
301
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
301
01:25Regulation of Water Intake
2.5K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.5K
02:34Water and Mineral Acquisition
35.1K
Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.1K