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Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats.

Luis Cobos-Puc¹, Pablo Urbina-Ruiz², Jorge Pacheco-Rosado³

¹Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México; Departamento de Biotecnología, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Coahuila, México.

Archives of Medical Research

|April 15, 2020

Summary

This summary is machine-generated.

Hypothyroidism impairs the blood pressure-lowering effects of 5-hydroxytryptamine (5-HT). This reduced vasodepressor response to 5-HT may contribute to hypertension in hypothyroid patients.

Keywords:

5-Hydroxytryptamine Hypertension Hypothyroidism Methimazole Vasodepressor response

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Area of Science:

Cardiovascular Physiology
Endocrinology
Neuropharmacology

Background:

Hypothyroidism is linked to diastolic hypertension.
5-Hydroxytryptamine (5-HT) regulates blood pressure via central and peripheral receptors.
Hypothyroidism alters 5-HT receptor density in rodent brains.

Purpose of the Study:

To investigate the impact of methimazole-induced hypothyroidism on peripheral cardiovascular responses to 5-HT.

Main Methods:

Determined vasopressor and tachycardic responses to 5-HT in pithed hypothyroid rats.
Assessed vasodepressor responses to 5-HT, 5-carboxamidotryptamine (5-CT), isoprenaline, and acetylcholine during methoxamine infusion.

Main Results:

Vasopressor and tachycardic responses to 5-HT were unaffected.
Vasodepressor responses to 5-CT and acetylcholine remained unchanged.
The vasodepressor response to 5-HT was reduced.
Isoprenaline's vasodepressor effect was enhanced at low doses and reduced at high doses.

Conclusions:

Hypothyroidism impairs the vasodepressor action of 5-HT.
This impairment may be a contributing factor to hypertension observed in hypothyroidism.