Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

25.3K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
25.3K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

91
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
91
Legal Guidelines for Documentation01:06

Legal Guidelines for Documentation

1.9K
The legal guidelines for nursing documentation are essential for ensuring accurate, professional, and ethical recording of patient care. The guidelines are discussed here:
1.9K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

335
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
335
Blinding01:11

Blinding

3.8K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K
Ethical Standards II01:23

Ethical Standards II

1.2K
Ethical standards are the backbone of nursing practice, guiding nurses as they interact with patients, families, and colleagues. These standards are crucial for providing safe, empathetic care centered on the patient's needs.
Nurses are entrusted with upholding various ethical principles and standards. Nurses forge solid therapeutic relationships using trust, empathy, autonomy, confidentiality, and professional competence.
Confidentiality is crucial, embodying respect for individual privacy...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low Abundance of Cytotoxic Natural Killer Cells in Peritoneal Metastasis from Appendiceal Adenocarcinoma Suggests Tumor Immune Escape.

Annals of surgical oncology·2026
Same author

Selective Organ Site Strategy Versus Debulking in Multiorgan Metastatic Colorectal Cancer: Lessons from the ORCHESTRA Trial.

Annals of surgical oncology·2026
Same author

Impact of Dedicated Care Coordination on Access to Multidimensional Support Services in Young-Onset Colorectal Cancer: A Pragmatic Trial.

JCO oncology practice·2026
Same author

Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.

Immunity·2026
Same author

Appendiceal Adenocarcinoma Cytoreduction Outcomes and Perioperative Serum Tumor Marker Levels.

JAMA network open·2026
Same author

Translating Microbiome Science Into Surgical Oncology: Insights From Global Colorectal Cancer Studies.

Diseases of the colon and rectum·2026

Related Experiment Video

Updated: Dec 24, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.3K

Why Human Subjects Research Protection Is Important.

Michael G White1

  • 1Department of Pediatric Cardiology, Ochsner Clinic Foundation, New Orleans, LA and The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA.

Ochsner Journal
|April 15, 2020
PubMed
Summary

Institutional Review Boards (IRBs) ensure ethical research with human subjects. Historical events and key documents shaped regulations, minimizing harm and emphasizing investigator responsibility for participant safety.

Keywords:
Ethics committees–researchethics–researchresearch subjects

More Related Videos

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
06:35

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue

Published on: September 12, 2018

13.2K
Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity
07:32

Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity

Published on: February 10, 2016

9.7K

Related Experiment Videos

Last Updated: Dec 24, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.3K
Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
06:35

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue

Published on: September 12, 2018

13.2K
Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity
07:32

Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity

Published on: February 10, 2016

9.7K

Area of Science:

  • Medical Ethics
  • Research Compliance
  • Human Subjects Protection

Background:

  • Institutional Review Boards (IRBs) are federally mandated to review research involving human subjects.
  • Ensuring ethical guidelines are met before participant enrollment is a core responsibility.
  • The history of human subjects research regulations is complex and has evolved over time.

Purpose of the Study:

  • To review the historical evolution of human subjects protection in research.
  • To examine egregious events and ethical analyses that shaped current regulations.
  • To highlight key documents influencing the ethics debate in human subjects research.

Main Methods:

  • Historical review of human subjects research.
  • Analysis of significant ethical documents and events.
  • Examination of federal regulations governing research with human participants.

Main Results:

  • Key documents like the Nuremberg Code, Belmont Report, and Moral Science have guided ethical considerations.
  • Historical events underscore the necessity of robust protections for research participants.
  • Current regulations aim to minimize harm to subjects participating in research.

Conclusions:

  • Regulations for human subjects protection have evolved to enhance safety.
  • Individual responsibility of investigators and IRBs is crucial for ethical research.
  • Understanding historical failures supports continuous improvement in subject safety and research ethics.