Related Experiment Video

Updated: Dec 24, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.3K

Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors

Yingying Che1, Lin Fu1

  • 1Institute of Chronic Disease, Qingdao Municipal Hospital, Qingdao University, Qingdao 266000, China.

Journal of Cancer
|April 15, 2020
PubMed

Insights

Alternative splicing, regulated by serine-arginine rich (SR) proteins like SRSF3 (SRp20), is crucial in cancer development. This review explores SRSF3

Area of Science:

  • Molecular Biology
  • Cancer Research
  • RNA Splicing

Background:

  • Alternative splicing generates diverse RNA isoforms with varied functions.
  • Aberrant splicing, particularly by SR proteins, is linked to cancer development.
  • SRSF3 (SRp20) is a key splicing factor implicated in numerous cellular processes.

Purpose of the Study:

  • To summarize the role of SRSF3-regulated alternative splicing in cancer cell biology.
  • To discuss the regulation of SRSF3 in tumorigenesis.
  • To highlight SRSF3 as a potential therapeutic target in cancer.

Main Methods:

  • Review of existing literature on SRSF3 function and alternative splicing in cancer.
  • Analysis of SRSF3's impact on cancer cell proliferation, migration, and invasion.
  • Discussion of SRSF3's regulatory mechanisms in tumor development.

Main Results:

  • SRSF3 deregulation is a hallmark of many cancers.
  • SRSF3-mediated alternative splicing influences critical cancer cell behaviors.
  • SRSF3 plays significant roles across different stages of tumor progression.

Conclusions:

  • SRSF3 is a critical regulator of alternative splicing in cancer.
  • Understanding SRSF3's role in tumorigenesis is essential for developing targeted therapies.
  • SRSF3 represents a promising therapeutic target for various cancers.
Keywords:
SRSF3alternative splicingbiological functionstumor

More Related Videos

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

15.4K
Using the E1A Minigene Tool to Study mRNA Splicing Changes10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

5.3K

Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.1K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.5K
Alternative RNA Splicing02:18

Alternative RNA Splicing

4.6K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.0K
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
10.5K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K