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Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
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RNA Binding Proteins and Non-coding RNA's in Cardiovascular Diseases

Parveen Bansal1, Malika Arora2

  • 1University Centre of Excellence in Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India. bansal66@yahoo.com.

Advances in Experimental Medicine and Biology
|April 15, 2020
PubMed

Insights

Cardiovascular disease (CVD) treatments face challenges. MicroRNAs (miRNAs) show promise as diagnostic biomarkers and therapeutic agents for CVD, offering new treatment avenues.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a major global health burden, characterized by chronic and progressive symptoms.
  • Current CVD therapies have limitations, including toxicity, complexity, and drug resistance.
  • RNA molecules, particularly microRNAs (miRNAs), present versatile therapeutic potential for various diseases.

Purpose of the Study:

  • To review recent advancements in miRNA research for cardiovascular disease.
  • To explore the role of miRNAs as diagnostic biomarkers and therapeutic agents in CVD.
  • To highlight the future potential of miRNAs in CVD treatment and personalized medicine.

Main Methods:

  • Literature review of current research on miRNAs in cardiovascular disease.
  • Analysis of miRNA mechanisms, including miRNA, RNA binding proteins, and siRNA.
  • Exploration of strategies for miRNA-based therapeutic development.

Main Results:

  • miRNAs are emerging as crucial players in the pathogenesis and progression of CVD.
  • miRNAs demonstrate potential as reliable diagnostic biomarkers for CVD.
  • miRNAs offer promising therapeutic strategies for managing and treating CVD.

Conclusions:

  • Understanding miRNA biology is key to translating RNA therapeutics into clinical practice for CVD.
  • miRNAs represent a significant future therapeutic target for cardiovascular diseases.
  • Developing 'micronomes' could identify novel miRNA-mRNA interactions for predictive diagnostics and targeted therapies.

Keywords:
AptamerCardiovascular disease (CVD)RNA Binding Proteins (RBPs)microRNA

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