Related Experiment Video
Updated: Dec 24, 2025
10:34
Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
Published on: July 22, 2016
24.2K
RNA Binding Proteins and Non-coding RNA's in Cardiovascular Diseases
Parveen Bansal1, Malika Arora2
1University Centre of Excellence in Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India. bansal66@yahoo.com.
Advances in Experimental Medicine and Biology
|April 15, 2020
Summary
Cardiovascular disease (CVD) treatments face challenges. MicroRNAs (miRNAs) show promise as diagnostic biomarkers and therapeutic agents for CVD, offering new treatment avenues.
Area of Science:
- Biomedical Science
- Molecular Biology
- Cardiology
Background:
- Cardiovascular disease (CVD) is a major global health burden, characterized by chronic and progressive symptoms.
- Current CVD therapies have limitations, including toxicity, complexity, and drug resistance.
- RNA molecules, particularly microRNAs (miRNAs), present versatile therapeutic potential for various diseases.
Purpose of the Study:
- To review recent advancements in miRNA research for cardiovascular disease.
- To explore the role of miRNAs as diagnostic biomarkers and therapeutic agents in CVD.
- To highlight the future potential of miRNAs in CVD treatment and personalized medicine.
Main Methods:
- Literature review of current research on miRNAs in cardiovascular disease.
- Analysis of miRNA mechanisms, including miRNA, RNA binding proteins, and siRNA.
- Exploration of strategies for miRNA-based therapeutic development.
Main Results:
- miRNAs are emerging as crucial players in the pathogenesis and progression of CVD.
- miRNAs demonstrate potential as reliable diagnostic biomarkers for CVD.
- miRNAs offer promising therapeutic strategies for managing and treating CVD.
Conclusions:
- Understanding miRNA biology is key to translating RNA therapeutics into clinical practice for CVD.
- miRNAs represent a significant future therapeutic target for cardiovascular diseases.
- Developing 'micronomes' could identify novel miRNA-mRNA interactions for predictive diagnostics and targeted therapies.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.6K
02:39lncRNA - Long Non-coding RNAs
3.3K
3.3K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
454
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
454
01:20Types of RNA
8.6K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
8.6K
01:23Types of RNA
72.2K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.2K
01:30Coronary Artery Disease I: Introduction
785
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
785