Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Code-free automated machine learning for OCT-based classification of vitreoretinal interface diseases.

International journal of retina and vitreous·2026
Same author

Effects of coenzyme Q10 on retinal inflammation in streptozotocin-induced diabetic rats.

BMC ophthalmology·2026
Same author

Quadrant-Specific Pain in Intravitreal Injection: A Systematic Review and Meta-analysis.

Ophthalmology and therapy·2026
Same author

Retinal and choroidal microvascular alterations in ıdiopathic pulmonary fibrosis: an OCTA study.

International ophthalmology·2026
Same author

Congenital Retinal Macrovessel with Pigment Epithelial Detachment.

Klinische Monatsblatter fur Augenheilkunde·2026
Same author

Systemic C-reactive protein levels and central serous chorioretinopathy: A systematic review with meta-analysis.

Acta ophthalmologica·2025

Related Experiment Video

Updated: Dec 24, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K

Cigarette smoking reduces deep retinal vascular density.

Mustafa Dogan1, Muberra Akdogan1, Furkan Fatih Gulyesil1

  • 1Department of Ophthalmology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Clinical & Experimental Optometry
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Cigarette smoking significantly reduces retinal vascular density in the deep capillary plexus, even at low pack-year exposure. Optical coherence tomography angiography (OCT-A) reveals these early microvascular changes in smokers.

Keywords:
cigarette smokingoptical coherence tomography angiographyvessel density

More Related Videos

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.5K
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

2.1K

Related Experiment Videos

Last Updated: Dec 24, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.5K
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

2.1K

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Public Health

Background:

  • Cigarette smoking is a major risk factor for numerous systemic diseases.
  • The impact of smoking on ocular microvasculature is an area of ongoing research.
  • Understanding these effects is crucial for early detection and prevention of smoking-related eye conditions.

Purpose of the Study:

  • To investigate the effects of cigarette smoking on retinal vascular parameters.
  • To quantify changes in retinal vascular density in smokers compared to non-smokers.
  • To assess the utility of optical coherence tomography angiography (OCT-A) in detecting smoking-induced vascular alterations.

Main Methods:

  • Cross-sectional study comparing 24 smokers with 26 age- and sex-matched non-smokers.
  • Comprehensive ophthalmic examinations were performed on all participants.
  • Optical coherence tomography angiography (OCT-A) was used to measure retinal vascular density in the deep capillary plexus.

Main Results:

  • Smokers had significantly lower total vascular density, parafoveal vascular density, and perifoveal vascular density in the deep capillary plexus compared to controls (p < 0.05).
  • The mean smoking exposure was 3.3 pack-years.
  • These vascular reductions were observed despite relatively low pack-year exposure.

Conclusions:

  • Cigarette smoking leads to measurable reductions in retinal vascular density.
  • These microvascular changes can be detected by OCT-A, suggesting it's a sensitive tool for early detection.
  • Smoking's detrimental effects on the microvasculature may manifest even at low levels of exposure.