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Indicators of inflammation in the pathogenesis of unstable angina

Yevheniia H Zaremba1, Olha V Smaliukh1, Olena V Zaremba-Fedchyshyn1

  • 1Department of Family Medicine From Faculty of Postgraduate Education, Danylo Halytsky National Medical University, Lviv, Ukraine.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|April 15, 2020
PubMed

Insights

Patients with unstable angina show elevated inflammatory markers and abnormal blood lipid profiles. These findings suggest an activated inflammatory process and lipid disorders, necessitating dietary changes and hypolipidemic agents.

Area of Science:

  • Cardiology
  • Biochemistry
  • Immunology

Background:

  • Coronary heart disease (CHD) involves complex pathophysiological processes.
  • Inflammation and lipid metabolism disorders are key contributors to CHD development.

Purpose of the Study:

  • To investigate the blood lipid spectrum.
  • To assess levels of anti-inflammatory cytokines and C-reactive protein in CHD patients.

Main Methods:

  • Studied 61 patients with unstable angina and 20 healthy controls.
  • Measured blood lipid profiles, C-reactive protein, fibrinogen, and pro-inflammatory cytokines.

Main Results:

  • Patients with unstable angina exhibited significantly increased total cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, and atherogenicity coefficient.
  • Elevated levels of C-reactive protein and pro-inflammatory cytokines (interleukin-1β, -6, -17, TNF-α) were observed.

Conclusions:

  • Unstable angina is associated with heightened inflammation, indicated by increased cytokines and C-reactive protein.
  • Significant disruptions in blood lipid spectrum were found in these patients.
  • Dietary modifications and hypolipidemic agents are recommended for managing lipid disorders in unstable angina.
Abstract

Keywords:
interleukinsunstable anginaC-reactive protein

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