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Updated: Dec 24, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.

Åsa Ehlén1,2, Charlotte Martin1,2, Simona Miron3

  • 1Institut Curie, PSL Research University, CNRS, UMR3348, F-91405, Orsay, France.

Nature Communications
|April 15, 2020
PubMed
Summary

BRCA2 phosphorylation by PLK1 is crucial for accurate chromosome segregation during mitosis. Disrupting this interaction leads to chromosome instability and aneuploidy, common in BRCA2-mutated cancers.

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