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Preoperative Serum Fibrinogen is Associated With Acute Kidney Injury after Cardiac Valve Replacement Surgery
Jing Juan Yang1, Wen Hua Lei2, Peng Hu3
1Department of Nephrology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1, Shangcheng Road, Yiwu, China.
Scientific Reports
|April 15, 2020
Summary
Preoperative serum fibrinogen levels are linked to a higher risk of acute kidney injury (AKI) following cardiac valve replacement surgery. Early identification of high-risk patients may improve outcomes.
Area of Science:
- Nephrology
- Cardiology
- Hematology
Background:
- Acute kidney injury (AKI) is a significant complication after open cardiac surgery, increasing mortality and hospital stay.
- Predictive markers for postoperative AKI are crucial for patient management.
Purpose of the Study:
- To investigate the association between preoperative serum fibrinogen levels and the risk of postoperative AKI in patients undergoing cardiac valve replacement.
- To evaluate the predictive value of serum fibrinogen for AKI development.
Main Methods:
- A cohort study of 3459 patients undergoing cardiac valve replacement surgery.
- AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
- Statistical analysis included logistic regression and receiver operator characteristic (ROC) curve analysis, with Synthetic Minority Oversampling Technique (SMOTE) applied for bias reduction.
Main Results:
- 510 (14.74%) patients developed postoperative AKI.
- Preoperative serum fibrinogen was independently associated with AKI (OR=1.211, p=0.001).
- Adding serum fibrinogen to predictive models improved AKI risk classification (c-statistic increased from 0.72 to 0.73, p<0.001).
Conclusions:
- Preoperative serum fibrinogen is a significant independent predictor of postoperative AKI in patients undergoing cardiac valve replacement.
- Serum fibrinogen measurement can enhance the accuracy of AKI risk prediction in this population.
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