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Updated: Dec 24, 2025

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection
Joana Vitallé1, Laura Tarancón-Díez2,3, María R Jiménez-Leon2
1Immunopathology Group, Biocruces Bizkaia Health Research Institute, Barakaldo.
Abstract:
: Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4 T lymphocytes.

