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Updated: Dec 24, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Published on: November 28, 2015

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Expression and Function of Toll-Like Receptor 10 (TLR10) in Diffuse Large B Cell Lymphoma, Acute Myeloid Leukemia,

Le Ge1, Lixia Xu1, Shan Lu1

  • 1Tianjin Neurosurgical Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|April 15, 2020
PubMed

Insights

Toll-like receptor 10 (TLR10) is highly expressed in certain cancers like lymphoma and leukemia. TLR10 may serve as a theranostic target and a biomarker for distinguishing primary central nervous system lymphoma from glioblastoma.

Area of Science:

  • Immunology
  • Oncology
  • Genomics

Background:

  • Toll-like receptors (TLRs) are key in innate immunity.
  • TLR10, an orphan receptor, has unclear roles in tumors.
  • Its functional and clinical relevance in cancer remain poorly understood.

Purpose of the Study:

  • To investigate the expression and clinical significance of TLR10 in various cancers.
  • To explore TLR10 as a potential biomarker for glioma and CNS-DLBC.
  • To assess TLR10's correlation with immune infiltrates.

Main Methods:

  • Analysis of TLR10 expression data from The Cancer Genome Atlas (TCGA) using UALCAN, GEPIA, CGGA, and TIMER.
  • Confirmation of expression via immunohistochemistry.
  • Correlation analysis with clinical parameters and immune cell infiltration.

Main Results:

  • TLR10 is highly expressed in diffuse large B cell lymphoma (DLBC), acute myeloid leukemia (LAML), and glioblastoma multiforme (GBM).
  • Higher TLR10 levels correlate with increased WHO grade in glioma and poorer overall survival (OS) and disease-free survival (DFS).
  • TLR10 expression positively correlates with immune cell infiltration, particularly B cells, and can distinguish CNS-DLBC (PCNSL) from GBM.

Conclusions:

  • TLR10 is a potential theranostic target for glioma patients.
  • TLR10 serves as a promising biomarker for differentiating PCNSL from GBM.
  • Further research into TLR10's role in cancer immunity is warranted.

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