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Published on: February 18, 2022
Putative structure and function of ORF3 in SARS coronavirus
1HKU-Pasteur Research Center, Department of Bioinformatics, 8 Sassoon Road, Pokfulam, Hong Kong, China.
Abstract:
Based on molecular modeling techniques we constructed a rational 3D model of ORF3 in SARS coronavirus (SARS-CoV). Our studies suggest that the function of ORF3 could be involved in FAD/NAD binding according to its predicted structure and comparison with other structure neighbors. Furthermore, we identified three pairs of non-canonical N-H⋯π interactions in the structure of ORF3, which can make contributions to the stability of protein structure. These results provide important clues for better understanding of SARS-CoV ORF3 and trying new therapeutic strategies.
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