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L Kramer1

  • 1Intensivstation Universitätsklinik für Innere Medizin IV Währinger Gürtel 18 - 20 A-1090 Wien Österreich E-mail: ludwig.kramer@akh-wien.ac.at, , , , XX.

Intensivmedizin + Notfallmedizin : Organ Der Deutschen Und Der Osterreichischen Gesellschaft Fur Internistische Intensivmedizin, Der Sektion Neurologie Der DGIM Und Der Sektion Intensivmedizin Im Berufsverband Deutscher Internisten E.V
|April 15, 2020
PubMed
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Plasmapheresis use in intensive care units (ICUs) has evolved, with validated indications now limited to severe immunological disorders. Future therapies may further reduce its role, necessitating a review of current applications and risks.

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Renal Replacement Therapy

Context:

  • Plasmapheresis was once broadly applied in intensive care units (ICUs) for immunological diseases.
  • Recent pathophysiological insights and clinical trials have narrowed its validated uses.
  • The role of plasmapheresis in ICUs has significantly changed over the past 20 years.

Purpose:

  • To review the current, validated indications for plasmapheresis in the ICU.
  • To summarize the known side-effects associated with plasmapheresis in critically ill patients.
  • To discuss the evolving landscape and potential future limitations of plasmapheresis therapy.

Summary:

  • Plasmapheresis is now primarily indicated for acute, severe immunological disorders unresponsive to standard immunosuppression or requiring substantial plasma volume replacement.
Keywords:
Key words Extracorporeal renal supportcomplicationsindicationsplasmapheresis

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  • Controlled trials and improved understanding of disease mechanisms have refined its application.
  • The review synthesizes current evidence on when plasmapheresis is appropriate in the ICU setting.

    • Impact:

    • Highlights the shift from broad application to specific, evidence-based indications for plasmapheresis.
    • Provides a concise summary of risks and benefits for clinicians managing critically ill patients.
    • Informs future research directions and the development of alternative immunomodulatory therapies.